Test Bank For Pharmacotherapeutics for Advanced Practice Nurse Prescribers 4th Edition By Robinson
Chapter 2. Review of Basic Principles of Pharmacology
Multiple Choice
Identify the choice that best completes the statement or answers the question.
____ 1. A patient’s nutritional intake and laboratory results reflect hypoalbuminemia. This is critical to prescribing because:
|
1. |
Distribution of drugs to target tissue may be affected. |
|
2. |
The solubility of the drug will not match the site of absorption. |
|
3. |
There will be less free drug available to generate an effect. |
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4. |
Drugs bound to albumin are readily excreted by the kidneys. |
____ 2. Drugs that have a significant first-pass effect:
|
1. |
Must be given by the enteral (oral) route only |
|
2. |
Bypass the hepatic circulation |
|
3. |
Are rapidly metabolized by the liver and may have little if any desired action |
|
4. |
Are converted by the liver to more active and fat-soluble forms |
____ 3. The route of excretion of a volatile drug will likely be the:
|
1. |
Kidneys |
|
2. |
Lungs |
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3. |
Bile and feces |
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4. |
Skin |
____ 4. Medroxyprogesterone (Depo Provera) is prescribed intramuscularly (IM) to create a storage reservoir of the drug. Storage reservoirs:
|
1. |
Assure that the drug will reach its intended target tissue |
|
2. |
Are the reason for giving loading doses |
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3. |
Increase the length of time a drug is available and active |
|
4. |
Are most common in collagen tissues |
____ 5. The NP chooses to give cephalexin every 8 hours based on knowledge of the drug’s:
|
1. |
Propensity to go to the target receptor |
|
2. |
Biological half-life |
|
3. |
Pharmacodynamics |
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4. |
Safety and side effects |
____ 6. Azithromycin dosing requires that the first day’s dosage be twice those of the other 4 days of the prescription. This is considered a loading dose. A loading dose:
|
1. |
Rapidly achieves drug levels in the therapeutic range |
|
2. |
Requires four- to five-half-lives to attain |
|
3. |
Is influenced by renal function |
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4. |
Is directly related to the drug circulating to the target tissues |
____ 7. The point in time on the drug concentration curve that indicates the first sign of a therapeutic effect is the:
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1. |
Minimum adverse effect level |
|
2. |
Peak of action |
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3. |
Onset of action |
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4. |
Therapeutic range |
____ 8. Phenytoin requires that a trough level be drawn. Peak and trough levels are done:
|
1. |
When the drug has a wide therapeutic range |
|
2. |
When the drug will be administered for a short time only |
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3. |
When there is a high correlation between the dose and saturation of receptor sites |
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4. |
To determine if a drug is in the therapeutic range |
____ 9. A laboratory result indicates that the peak level for a drug is above the minimum toxic concentration. This means that the:
|
1. |
Concentration will produce therapeutic effects |
|
2. |
Concentration will produce an adverse response |
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3. |
Time between doses must be shortened |
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4. |
Duration of action of the drug is too long |
____ 10. Drugs that are receptor agonists may demonstrate what property?
|
1. |
Irreversible binding to the drug receptor site |
|
2. |
Upregulation with chronic use |
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3. |
Desensitization or downregulation with continuous use |
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4. |
Inverse relationship between drug concentration and drug action |
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